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Oligopeptide is a short-chain peptide composed of 2-10 amino acids connected by peptide bonds, with a molecular weight range of 200-1000 Da. Compared with peptides (10-50 amino acids) and proteins (>50 amino acids), oligopeptides have the characteristics of small molecular weight, high transdermal absorption rate, and strong targeting. They are widely used in anti-aging, repair, whitening and other functional skin care products and medical regeneration materials. |
Type | Representative sequences | Core functions |
Signal peptide | Pal-KTTKS | Stimulate fibroblasts to synthesize collagen (130% type I collagen), reduce wrinkle depth. |
Neurotransmitter inhibitory peptide | Acetyl hexapeptide-8 (Argireline) | Inhibit SNARE complex formation, relax facial muscles (dynamic lines reduced by 27%). |
Carrier peptide | Copper peptide (GHK-Cu) | Combines copper ions to promote wound healing (LOX enzyme activity 140%), anti-oxidation (ORAC value |
Whitening peptide | Nonapeptide-1 (Nonapeptide-1) | ≥5000 μmol TE/g). |
Antibacterial peptide | Gramicidin S | Inhibit tyrosinase activity (135% melanin production), lighten spots. |
Parameters | Specifications | |
Purity | ≥95% (HPLC detection), impurities (such as free amino acids, solvent residues) ≤1%. | |
Molecular weight | Target peptide ±2 Da (mass spectrometry verification), amino acid sequence accuracy ≥99% (Edman degradation or NMR confirmation). | |
Stability | Liquid: pH 5-7, 4-25ºC dark storage (6-month activity retention ≥90%); Powder: moisture ≤3%, shelf life 24 months. | |
Safety | Total microbial count ≤100 CFU/g, no pathogenic bacteria (Salmonella/Escherichia coli not detected), patch test negative rate ≥99%. |
1. Anti-aging skin care products
• Essence: 0.5% palmitoyl tripeptide-1 + 1% hyaluronic acid + 0.2% retinol (slow release), improve collagen density.
• Eye cream: 3% acetyl octapeptide-3 (SNAP-8) + caffeine, reduce dynamic lines around the eyes.
2. Medical repair dressings
• Postoperative gel: 0.1% blue copper peptide (GHK-Cu) + 2% asiatica glycoside, accelerate wound healing (clinical data: healing time is shortened by 40%).
3. Whitening and spot-lightening products
• Ampoule: 2% nonapeptide-1 + 4% niacinamide + 1% tranexamic acid, inhibit melanin transport and synthesis.
4. Scalp care
• Anti-hair loss shampoo: 0.01% myristoyl tetrapeptide-12 + 1% caffeine, activate hair follicle stem cells (hair density↑15%).