High Purity Berberine Hydrochloride Plant Extract for Blood Sugar Management
Berberine hydrochloride (CAS No.: 633-65-8) is an isoquinoline alkaloid with a chemical formula of C20H18ClNO4 and a molecular weight of 371.81. It is naturally present in plants such as Coptis chinensis, Phellodendron chinense, and Tripterygium wilfordii, and can also be prepared by chemical synthesis. It appears as a yellow crystalline powder, slightly soluble in cold water, easily soluble in hot water, and almost insoluble in ethanol, chloroform, and ether.
| Item Specification |
| Berberine Hydrochloride |
≥10% |
| Appearance &Color |
Yellow crystalline powder,inodorous,extremely bitter |
| Identification |
Be positive reaction under test procedures |
| Loss on drying |
≤12% |
| lgnition residue |
≤0.2% |
| Other alkaloid |
Comply with the hygiene requirements |
| Heavy Metals |
| Total Heavy Metals |
≤10ppm |
| Arsenic(As) |
≤2ppm |
| Lead(Pb) |
≤2ppm |
| Cadmium(Cd) |
≤0.2ppm |
| Mercury(Hg) |
≤0.2ppm |
| Microbiology |
| Total Plate Count |
≤1000cfu/g |
| Total Yeast &Mold |
≤100cfu/g |
| E.Coli |
Negative |
| Salmonella |
Negative |
1. Management of metabolic diseases
• Blood sugar reduction
• Regulate blood lipids: Reduce low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), and increase high-density lipoprotein cholesterol (HDL-C).
• Weight control: Its mechanism may be related to inhibiting lipogenesis and promoting energy consumption.
2. Anti-inflammatory and immune regulation
• Intestinal infection: Traditionally used to treat bacillary dysentery and acute gastroenteritis, inhibit pathogen proliferation and enhance leukocyte phagocytosis.
• Arthritis: Reduce the release of inflammatory factors (such as TNF-α, IL-6) by blocking the NF-κB pathway, and relieve rheumatoid arthritis symptoms.
3. Cardiovascular protection
• Anti-arrhythmia: Inhibit myocardial cell calcium ion overload, prolong the action potential duration, and be used as an adjuvant treatment for atrial fibrillation and ventricular premature beats.
• Anti-atherosclerosis: Reduce oxidative stress and vascular endothelial damage, and delay plaque formation.
4. Anti-tumor potential
• In vitro experiments have shown that it can induce apoptosis of cancer cells (such as B16 melanoma cells) and inhibit tumor angiogenesis.
1. Medicine and Clinical
• Intestinal diseases: treatment of bacillary dysentery, irritable bowel syndrome (IBS)-related diarrhea
• Metabolic syndrome: as a dietary supplement, used for prediabetes and obesity management.
2. Daily chemicals and skin care products
• Anti-acne formula: added to cleansing products to inhibit the growth of Propionibacterium acnes.
• Antioxidant essence: compounded with vitamin C to reduce UV-induced skin oxidative damage.
3. Food industry
• Functional beverages: develop blood sugar-lowering and liver-protecting beverages, such as "berberine herbal tea".
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