GMP Veterinary Medicine Factory Cattle Sheep Medicines Ivermectin CAS70288-86-7
Ivermectin is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod, canine intestinal nematodes, ear mites, scabies mites,silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry.
This product belong to the broad-spectrum drug resistant parasites.
Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role;For dish tail filarial microfilariae effectively, but for adult worms; For only in intestinal fecal round worms are also effective.
1. Antiparasitic mechanism:
• By enhancing the activity of glutamate-gated chloride channels, it causes hyperpolarization of parasite nerve and muscle cells, blocks nerve signal transmission, and eventually causes paralysis and death.
• It is effective against nematodes (such as roundworms, hookworms) and arthropods (such as scabies mites, lice), but ineffective against tapeworms and flukes.
2. Pharmacokinetics:
• Oral absorption is good, the peak blood drug concentration (Cmax) is reached in 4-5 hours, the half-life is about 18 hours, 93% is bound to plasma proteins, and is excreted in the feces after metabolism by liver CYP450.
• Low blood-brain barrier penetration and high mammalian safety.
1. Human medicine:
• Parasitic infections:
River blindness (onchocerciasis): single oral dose of 150-200 μg/kg, annual dose can prevent blindness.
Strongyloidiasis: single dose of 200 μg/kg, repeated if necessary.
Scabies: topical application or oral administration, with an efficacy of over 90%.
• Other explorations: anti-cancer (inducing apoptosis, inhibiting Wnt/β-catenin pathway), antiviral and other studies, but clinical evidence is limited.
2. Veterinary medicine and agriculture:
• For gastrointestinal nematodes and external parasites (such as maggots and mites) of cattle, sheep and pigs, subcutaneous injection or oral dose of 0.2 mg/kg.
• Agricultural pesticides: control plant nematodes and pests, safer than traditional pesticides.
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